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The aim of Aging Cell is to publish novel and exciting research that addresses fundamental issues in the biology of aging. For publication in Aging Cell the work must provide a significant new contrib
在线投稿说明
Author Guidelines
Aging Cell&publishes regular research articles, short format articles, reviews, and commentaries. (1) The principal content is full Research Reports of 6-10 printed pages presenting new findings of significant scope and depth. (2) Short Take articles that report brief accounts of new findings that are likely to be of high interest and importance. (3) Review articles that present an overview and creative perspective on topics of high interest to biogerontologists. Unsolicited reviews are welcome. Authors who are considering the submission of an unsolicited review article are encouraged to contact the Reviews Editor prior to submission to discuss the topic and scope of the proposed review. (4) The editors will from time to time commission Hot Topics, Viewpoint articles, or other commentaries areas of current interest.
All submissions are subject to peer review by the editorial team and by selected outside referees. The editors, with the advice of the editorial board, evaluate each submitted manuscript and will notify authors within 5-10 days if in their view the paper is unlikely to receive a high priority for publication. Papers that have been evaluated to be of low priority are returned to the authors as soon as possible so that they can be submitted elsewhere. For papers that are sent out for expert outside review the Aging Cell strives to provide authors with a first decision within four weeks.
Authors of commissioned or solicited reviews will not be charged for colour illustrations. Supporting Information that is deemed to be essential for a full understanding and reproducibility of the research presented is welcome and will be published in the online edition only. When appropriate, Supporting Information should include raw data from, for example, longevity or gene expression studies. All Supporting Information is reviewed by the outside reviewers and the editors.
Submission of manuscriptsImportant Note to Authors: submission requirements for Aging Cell have changed. Due to the high volume of papers submitted to the Journal, limits have been imposed on the character count of articles, the number of figures, references, and so forth.
General Information
Aging Cell&now accepts submissions online at&.&All authors should read and apply the instructions, including specifications of file types for text and illustrations given on the site. Should authors encounter difficulties they may contact the ScholarOne support desk at 434 817 2040 ext. 167 or via E-mail at:&.
Authors who cannot submit their manuscripts online should contact the Managing Editor, Stephanie Waller, Aging Cell, King's College London, James Clerk Maxwell Building, 57 Waterloo Road, London SE1 8WA. E-mail:&.
The Editors-in-Chief will choose a Supervising Editor in an appropriate field of interest to supervise the review of each article. Authors are requested to provide a list of up to five possible reviewers, including, if appropriate (given their areas of expertise), members of the&Aging CellEditorial Board. Papers considered to be outside the field of interest of the Journal will be returned without delay. All questions about the status of manuscripts under review should be directed to the Editorial Office. Please use the e-mail address&&for such enquiries. &Pre-submission enquiries and questions about scientific matters can be addressed to any of the Editors-in-Chief: Adam Antebi (), Ana Maria Cuervo (), Brian Kennedy () or John Sedivy ().&Pre-submission enquiries concerning Reviews should be addressed to the Reviews Editor, George Martin (
Papers are accepted on the understanding that no substantial part has been, or will be, published elsewhere. If accepted, papers become the copyright of Wiley-Blackwell and the Anatomical Society of Great Britain & Northern Ireland.
The journal to which you are submitting your manuscript employs a plagiarism detection system. By submitting your manuscript to this journal you accept that your manuscript may be screened for plagiarism against previously published works
Pre-submission English-language editingAuthors for whom English is a second language may choose to have their manuscript professionally edited before submission to improve the English. A list of independent suppliers of editing services can be found at&.&All services are paid for and arranged by the author, and use of one of these services does not guarantee acceptance or preference for publication.
Preparation and presentation of manuscriptsAll manuscripts must be submitted online to&&&and must conform to the specifications given on the website. Only manuscripts in English will be published. Spelling should conform to that in&The Concise Oxford Dictionary&or&Webster’s New Collegiate Dictionary.The title page should include: (1) the full title of the paper-&titles should be no more than three typeset lines (approximately 126 characters including spaces); (2) the full name (3) the name(s) and address(es) of the institution(s) at which the work was carried out (the present addresses of the authors, if different from the above, should appear in a footnote); (4) the name, address, telephone and fax numbers and e-mail address of the author to whom all correspondence and p (5) the e-mail addresses of all the (6) a suggested running title of not more than 50 characters, (7) six key words to aid indexing.
Primary Research Papers
Articles longer than&9 pages when in proof will be subject to a page charge for excess journal pages above that limit,&of ?50 for each additional complete or partial page over 9 print pages. &Authors will have to consult the corresponding Editor in Chief if their manuscript is expected to exceed 9 printed journal pages (that is, expand beyond a limit of 50,000 characters, plus up to 2pp of figures). The maximum character count of 50,000 characters (including spaces) is imposed to all sections (see below) with the exception of the Title Page, Checklist, Tables and Figures. Figure Legends are to be included in the character count. The character count will remain in effect for articles resubmitted in response to review. In addition, up to 2 pages of figures are allowed. Download&
Papers should be divided into the following sections and appear in the order: (1) Title P (2) C (3) Summary, not to exceed 250 (4) I (5) R (6) D (7) Experimental P (8) A (9) Author C (10) R (11) Supporting Information listing, (12) T (13) F (14) Figures. The Results and Discussion sections may contain subheadings. Experimental Procedures should be sufficiently detailed to enable the experiments to be reproduced, and may in part appear as Supporting Information (see below).
All pages must be numbered consecutively from the title page, and include the Acknowledgments, References, Tables, and Figure Legends.
Short TakesThe Editors-in-Chief will consider short papers that report findings of exceptional relevance and interest. While most authors prefer to develop such findings into a larger story that provides significant mechanistic insights, in some cases the findings may be so novel or important to the field that their rapid dissemination takes precedence. Short Takes can have a maximum of 10,000 characters, defined as above for Primary Research Papers. In addition, Short Takes are limited to two Figures (or one Figure and one Table, or two Tables). The Introduction, Results and Discussion sections should be merged into one continuous text. Experimental Procedures are to be included as online Supporting Information.
ReviewsAuthors are encouraged to contact the Reviews Editor,&John M. Sedivy ()with a pre-submission enquiry on their proposed topic and scope prior to submission. Preference will be given to short, focused reviews of approximately 20,000 characters. The Summary is to be included in the character count and should be less than 250 words. The rest of the article is to be a continuous narrative. Subheadings may be used.& Some reviews may necessitate the citing of relevant original literature, and hence the References are not included in the character count, but in all cases the authors should be as concise with the References as possible. The Editors welcome suggestions for reviews.
CommentariesThe Editors-in-Chief will commission commentaries on seminal articles published in&or elsewhere. The format is to follow that of Short Takes, above. Suggestions of appropriate papers are welcomed.
Units and abbreviationsFor approved abbreviations and symbols please see (). These standard abbreviations may be used in the title and abstract. Any abbreviations used in the title and abstract that are not on this list (nonstandard abbreviations) must be spelled out in full words followed by the abbreviation in parentheses. Standard abbreviations can also be used throughout the text of the article, notwithstanding how many times they are used. Nonstandard abbreviations can only be used if they occur more than three times within the text of the article. At the point of first use they must be spelled out in full words followed by the abbreviation in parentheses.
Scientific nomenclatureComplete scientific names should be given when organisms are first mentioned. The generic name may subsequently be abbreviated to the initial. It is important to differentiate between genes and proteins. All gene names and l proteins should be upright.
ChecklistA separate&&Page should be provided, immediately following the Title Page. It should contain the following information: (1) t (2) word count of the S (3) the number of papers cited in the R (4) a listing of all Tables (Table 1, Table 2, etc.); (5) a listing of all Figures (Fig. 1, Fig. 2, etc.) including, (a) whether the Figure should be in colour, greyscale or black and white, (b) whether the Figure should appear in 1-column or 2-column format, (c) the size of the Figure at full scale (mm x mm), (d) the smallest font size used in the Figure at full scale.
Experimental ProceduresTrade names should be capitalized. The manufacturer's name should be followed by an address including town, (state, if USA) and country.
Author ContributionsAuthors are encouraged to include a brief statement to specify the contributions of each co-author, to appear immediately before the References. The statement should not be more than several sentences long, describing the task of individual authors. Further information on authorship and contributorship may be found at http://www.icmje.org/#author.
ReferencesA maximum of 45 references will be allowed for Primary Research Papers, and 20 references for Short Takes. There is no limit on the number of references for Reviews, but authors should be as concise as possible. In the text references should be cited by author and date, e.g. Shah & Klessig (1999). Joint authors should be referred to by et al. if there are more than two, e.g. Sambrook et al. More than one paper from the same author(s) in the same year must be identified by the letters a, b, c, etc., placed after the year of publication. In the References section at the end of the paper, references should be listed alphabetically according to the first named author. The full titles of papers, chapters and books should be given, the abbreviated names of journals, with the first and last page numbers.
ExamplesWhittemore SR, Nieto-Sampedro M, Needels DL, Cotman CW (1985) Neuronotrophic factors for mammalian brain neurons: injury induction in neonatal, adult and aged rat brain. Brain Res. 352, 169-178. Willot JF (1999) Neurogerontology: Aging and the Nervous System. New York: Springer Publishing Company, Inc. Cotman CW (1990) Synaptic plasticity, neurotrophic factors, and transplantation in the aged brain. In Handbook of the Biology of Aging (Schneider EL, ed). San Diego: Academic Press, pp. 617-644.
Work that has not been accepted for publication and personal communications should not appear in the reference list, but may be referred to in the text. It is the authors' responsibility to obtain permission from colleagues to include their work as a personal communication.
We recommend the use of a tool such as&&or&&for reference management and formatting.EndNote reference styles can be searched for here:Reference Manager reference styles can be searched for here:
Supporting InformationSupporting Information, such as additional Figures, Tables, or other data sets (including raw data, if appropriate) can be submitted. This information will not be published in the printed edition of the journal, but will be viewable in the online edition. Supporting Information should be succinct and designed with the aim to allow a complete and full understanding of the manuscript. Authors are encouraged to shift material of secondary importance to the online Supporting Information. One instance where this can be especially useful is with Experimental Procedures: while it is desirable to provide as much relevant detail as possible to facilitate others to reproduce the experiments, many important details such as buffer compositions, vendor information, catalog numbers, additional references, etc. take up too much space in the printed journal and can be moved to the Supporting Information.
It should be clearly stated at the time of submission that the Supporting Information is intended to be made available through the online edition. The availability of Supporting Information should be indicated in the main manuscript by a paragraph, to appear after the References, entitled Supporting Information, and listing the titles of Figures, Tables, etc. that will appear in the online edition. The Supporting Information should be submitted to the Editorial Office either in final form, ready for viewing, or as a URL allowing access to the Editorial Office and reviewers. This Supporting Information is an integral part of the article and will be reviewed accordingly. Further details are available at&. No changes can be made after the final acceptance of the paper by the Authors, Editorial Office, or the Publisher.
Two areas are highlighted where this practice is obligatory: submission of lifetime survival studies, and submission of microarray data. For survival studies, for each survival or mortality plot, authors should provide the raw data in the form of a Table to allow replication of the presented analysis and to facilitate independent analysis and cross-study comparisons. The table should be formatted with, as a minimum, the following columns: age- number entering the age-interval (Nx); number dead within the age interval (Dx); number censored within the age interval (Cx). It is not required, but may be included at the author's choice, to present life table statistics as additional columns (e.g., period and cumulative survival, life expectancy, hazard, etc.). For each Figure, a separate Table should be provided and clearly associated with the Figure. The Table should be organized such that each cohort (the group that constitutes data for a single line in the Figure) is represented as an independent subsection. Thus, in Excel, separate worksheets should be used for each cohort. The labels of the worksheets should correspond to the labels used in the Figure Legend. In a tab-delimited text file, the subsections should be stacked and each subsection should be labeled with a subheading used in the Figure Legend.
For microarray data, sufficient information should be provided to allow replication of results as well as independent re-analysis of the data: (1) type of array used, method of RNA extraction, labeling, hybridization, washing and a (2) full description of norm (3) a detailed description of the statistical analyses and data mi (4) an independent method (typically qPCR) should be used to validate the results for some of the genes identified as differentially expressed with, where possible, a rationale for the (5) the raw, complete data set should be tabulated and provided in order to facilitate independent analysis and cross-study comparisons.
TablesPrimary Research Papers can contain a maximum of two Tables (in addition to the six Figures, below). If more Tables are needed, they should replace some of the Figures, or can be placed in the Supporting Information. Tables should be set out on separate pages and saved in Word format. They should have a brief descriptive title and be self-explanatory. Units should appear in parentheses in the column headings, not in the body of the table.
Figure LegendsFigure legends should be typed on separate sheets and must contain sufficient information to be understood without reference to the text. Legends should not contain methods. Each should begin with a short title for the figure. All symbols and abbreviations used in the figures should be explained. In the full-text online edition of the journal, figure legends may be truncated in abbreviated links to the full-screen version. Therefore, the first 100 characters of any legend should inform the reader of key aspects of the figure.
FiguresA Primary Research Paper may contain up to 6 figures and a Short Take up to 2 figures. Figures may have multiple panels. The journal prefers figures to appear at 1-column (80 mm) or 2-column (167 mm) width, and authors are encouraged to make as efficient use of this space as possible. The maximum height is 231 mm. Authors are encouraged to provide figures in the size that they are to appear in the journal. All fonts in the figures must be a minimum of 6 pt in size as printed in the journal. If authors provide figures that need to be scaled to conform to the one or two column format, they must indicate whether each figure is to appear as one or two columns, and if this results in any font being smaller than 6 pt that figure will be returned to the authors for reworking.
Vector graphics (e.g. line artwork) should be saved in EPS encapsulated postscript format (.eps) or PDF portable document format (.pdf). Photographic images should be saved in TIFF tagged image file format (.tif). Figures containing a combination of photographic images and text (e.g. annotated photographic images with text labels) should be saved as EPS or PDF. Any photographic images embedded within these should be at least 300 dpi. Initial submissions will be accepted in .jpg format in order to facilitate electronic transmission for reviewing. Detailed information on our digital illustration standards are available at&Wherever possible please also supply high quality hard copy figures at the time of manuscript acceptance.
The journal welcomes colour illustrations. Reviews and mini-reviews can include colour illustrations free of charge. Please refer to&for details of the cost of colour reproduction for all other articles. Under exceptional circumstances, authors may request waiver of these charges. This must be done, in writing, at the time of submission of the manuscript, and authors must justify to the Editors that inclusion of the figure(s) in colour is essential for interpretation of the results presented.
Post-acceptance processing
ProofsThe corresponding author will receive an e-mail alert containing a link to a web site. A working e-mail address must therefore be provided for the corresponding author. The proof can be downloaded as a PDF file from this site. Acrobat Reader will be required in order to read this file. This software can be downloaded (free of charge) from the following web site/products/acrobat/readstep2.html.
This will enable the file to be opened, read on screen and printed out in order for any corrections to be added. Further instructions will be sent with the proof. Hard copy proofs will be posted if no e-mail address is available. Excessive changes made by the author in the proofs, excluding typesetting errors, will be charged separately. Major alterations to the text will be charged to the author and may delay publication.
Exclusive Licence FormAuthors will be required to sign an Exclusive Licence Form (ELF) for all papers accepted for publication. Signature of the ELF is a condition of publication and papers will not be passed to the publisher for production unless a signed form has been received. Please note that signature of the Exclusive Licence Form does not affect ownership of copyright in the material. Government employees need to complete the Author Warranty sections, although copyright in such cases does not need to be assigned. After submission authors will retain the right to publish their paper in various medium/circumstances (please see the form for further details). To assist authors an appropriate form will be supplied by the editorial office. The form can also be downloaded from.&Authors that would like their articles to be published&&can access the online form
Colour work agreementIt is the policy of Aging Cell for authors to pay the full cost for the reproduction of their colour artwork in print for all articles other than Reviews and Commentaries. In the event that an author is not able to cover the costs of reproducing colour figures in colour in the printed version of the journal, Aging Cell offers authors the opportunity to reproduce colour figures in colour for free in the online version of the article (but they will appear in black and white in the print version). Authors that wish to take advantage of this free colour-on-the-web service should liaise with the Editorial Office to ensure that the appropriate documentation is completed for the Publisher.
Please note that if there is colour artwork in a manuscript when it is accepted for publication, Wiley-Blackwell will require the authors to complete and return a Colour Work Agreement Form which can be downloaded from&&The form can also be obtained by FAX or e-mail from the Editorial Office. Once completed, the form should be returned to the Production Office, Aging Cell, John Wiley & Sons Singapore Pte. Ltd., 1 Fusionopolis Walk, #07-01 Solaris South Tower, Singapore 138628. Fax: +(65) . E-mail:&&Any article received by Wiley-Blackwell with colour work will not be published until the form has been returned.
Author material archive policyPlease note that unless specifically requested, Wiley-Blackwell will dispose of all hardcopy or electronic material submitted four months after publication. Authors that wish the return of any material submitted, should inform the editorial office or production editor as soon as possible.
Accepted Articles Published Online ahead of PrintArticles in this journal which have been peer-reviewed and accepted, but not yet copy-edited, are published online through our Accepted Article feature in advance of print publication -&&At this time Supporting Information cannot be published at the Accepted Article stage. Any required Supporting Information will be available online from the Early View stage.
Early ViewAging Cell is covered by the Wiley-Blackwell Early View service. Early View articles are complete full-text articles published online in advance of their publication in a printed issue. Articles are therefore available as soon as they are ready, rather than having to wait for the next scheduled print issue. Early View articles are complete and final. They have been fully reviewed, revised and edited for publication, and the authors' final corrections have been incorporated.
Because they are in final form, no changes can be made after online publication. The nature of Early View articles means that they do not yet have volume, issue or page numbers, so Early View articles cannot be cited in the traditional way. They are therefore given a Digital Object Identifier (DOI), which allows the article to be cited and tracked before it is allocated to an issue. After print publication, the DOI remains valid and can continue to be used to cite and access the article. More information about DOIs can be found at&.
OffprintsFree access to the final PDF offprint or your article will be available via author services only. Please therefore sign up for author services if you would like to access your article PDF offprint and enjoy the many other benefits the service offers.
Cover photographPhotographs of high quality suitable for the cover of&Aging Cell&are welcomed. They should be sent to the Editors and be accompanied by a brief descriptive summary. It is preferred, but not essential, that these should be related to submitted papers, for more information see.
Online production tracking is now available through Author ServicesAuthor Services enables authors to track their article - once it has been accepted - through the production process to publication online and in print. Authors can check the status of their articles online and choose to receive automated e-mails at key stages of production. Authors will receive an e-mail with a unique link that will enable them to register and have their article automatically added to the system. Please ensure that a complete e-mail address is provided when submitting the manuscript. Visit&&for more details on online production tracking and for a wealth of resources including FAQs and tips on article preparation, submission and more.
NIH-funded authors and&Aging CellThe NIH mandates grantees to deposit their peer-reviewed author manuscripts in PubMed Central, to be made publicly available within 12 months of&. The NIH mandate applies to all articles based on research that has been wholly or partially funded by the NIH and that are accepted for publication on or after April 7, 2008. In order to help authors comply with the NIH mandate, for papers accepted for publication in&Aging Cell, Wiley-Blackwell will post the accepted manuscript (incorporating all amendments made during peer review, but prior to the publisher's copy-editing and typesetting) of articles by NIH grant-holders to PubMed Central at the point of acceptance by the journal. This version will then be made publicly available in PubMed Central 12 months after publication. Following the deposit Wiley-Blackwell authors will receive further communications from the NIH with respect to the submission. For further information, see&.
&If authors wish to make their final published article openly accessible and without a 12 month embargo, they can choose to publish via the&&service.Wellcome trust and HHMI grantees can find out further information&.
OnlineOpenOnlineOpen is available to authors of primary research articles who wish to make their article available to non-subscribers on publication, or whose funding agency requires grantees to archive the final version of their article. With OnlineOpen the author, the author's funding agency, or the author's institution pays a fee to ensure that the article is made available to non-subscribers upon publication via Wiley Online Library, as well as deposited in the funding agency's preferred archive. For the full list of terms and conditions, see&.
The order form for OnlineOpen can be found at:.&Prior to acceptance there is no requirement to inform the Editorial Office of intent to publish OnlineOpen. All OnlineOpen articles are treated in the same way as any other article. They go through the journal's standard peer-review process and will be accepted or rejected based on their own merit.
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