如何使用kernel 来估算gevd的系数估算法

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& Continuous‐Pressure Controlled, External Ventricular Drainag...
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Neurosurgery:
Clinical Study
Continuous‐Pressure Controlled, External Ventricular Drainage for Treatment of Acute Hydrocephalus—Evaluation of Risk Factors
Bogdahn, U. M.D.; Lau, W. M.D.; Hassel, W. Grad. Eng.; Gunreben, G. M.D.; Mertens, H. G. M.D.; Brawanski, A. M.D.
EXPERIENCE WITH A continuous-pressure controlled, external ventricular drainage system (EVD) in 100 patients (n = 49 female, n = 51 mean age, 56.3 yr) with acute hydrocephalus is reported. Cerebrospinal fluid circulation disturbances resulted from hemorrhages caused by subarachnoid hemorrhage (n = 45), parenchymal hemorrhages from angioma (n = 4), anticoagulants (n = 7), or hypertension or other reasons (n = 30); in addition, hydrocephalus developed from infections (n = 3), tumors (n = 2), infratentorial infarction (n = 5), or unknown reasons (n = 4); 52 patients had ventricular hemorrhages. No patient died of system-associated morbidity. Mean time of EVD treatment was 9.5 days, with 40 patients being treated for 10 to 29 routine refobacin (5 mg) flushing of the system was performed three times a day. Patients without cerebrospinal fluid leakage had a 2% rate of secondary infection compared with 13% in patients with cerebrospinal fluid leakage due to ventricular catheter placement (P & 0.05; overall infection rate, 5%). A clinical mortality rate of 29% during EVD treatment was observed in subarachnoid hemorrhage patients (Hunt and Hess Grades II, III, IV, and V; n = 9, 9, 18, and 9, respectively); recurrent hemorrhages during EVD treatment occurred in 19 patients (26 hemorrhages), and of these, 10 patients died. System occlusion was seen in 19 cases (12 of 45 patients with subarachnoid hemorrhage), requiring catheter and system renewal in 1 system extraction was seen in 3 cases, misplacement was seen in 11 cases, and disconnection was seen in 5 cases. We conclude that EVD treatment with a modern aseptic system and continuous pressure monitoring has no additional mortality, as well as an acceptable rate of secondary infections and tec the poor prognosis patient selection may be responsible for a relatively high frequency of recurrent hemorrhages. Continuous pressure monitoring allows regular monitoring of intracranial pressure, early recognition of system occlusion, and recurrent hemorrhage.
Neurosurgery. 31(5):898-904, November 1992.
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Aneurysms, Antibiotic therapy, Central nervous system infection, Central nervous system tuberculosis, Hydrocephalus, Refobacin, Shunt infections, Subarachnoid hemorrhage, Ventricular drainage
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SU‐GG‐T‐589: Kernel Based Dose Calculation in Heterogeneous Media Using Fast Fourier Transform
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Med. Phys. 37, 3323 (Tue Jun 01 00:00:00 UTC 2010);
Purpose: This study evaluates the accuracy of the scatterdose calculation using FFT method in heterogeneous medium against Monte Carlo simulation.Method and Materials: Point spread kernels for scatterdoses are generated using Monte Carlo simulation in water for both 6X and 15X photon beams. Primary collision kerma Kc and scerma Scp, are determined using the photon energy spectrum Φ (E) as,
respectively, where the mass scattering coefficient μs/r = μ/r - μen/r. Note that beam hardening effects in primary collision kerma and scerma have been corrected at different depth by e -μ(E)l
. Heterogeneity is accounted for by a fast ray‐ racing algorithm developed in‐house which determines the radiological length distribution within the heterogeneous phantom. The fast ray‐ racing algorithm is capable of accommodating both divergent and parallel beams when calculating the primary collision kerma and scerma. The kernels are assumed to be space invariant and fast Fourier transform is used to evaluate the convolution integral. The scatterdose is obtained as the convolution between the scatter kernel and scerma. Results: Two cylindrical heterogeneous lung phantoms, one narrow and the other wide, are used to examine the accuracy of this method. It is found that the ray‐ racing algorithm can calculate both the kerma and scerma to within 1%. Convolutions of the kerma and scerma with the scatter kernel are evaluated against the results obtained from full Monte Carlo simulation to examine the beam hardening correction factor. Effect of beam divergence is also evaluated by comparing divergent and parallel beams. Conclusion: Kernel based real‐ ime dose calculation is a fast and viable alternative to the current correction‐ased treatment planning system. In this implementation, we implemented a fast ray‐ racing algorithm that accounts for heterogeneity and incorporates the beam hardening effect. Initial testing shows that the accuracy is within 1% of full Monte Carlodose simulation.
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SU‐GG‐T‐589: Kernel Based Dose Calculation in Heterogeneous Media Using Fast Fourier Transform
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SU‐GG‐T‐589: Kernel Based Dose Calculation in Heterogeneous Media Using Fast Fourier Transform
Med. Phys. 37, 3323 (Tue Jun 01 00:00:00 UTC 2010);
/content/aapm/journal/medphys/37/6/10.8990
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Scitation: SU‐GG‐T‐589: Kernel Based Dose Calculation in Heterogeneous Media Using Fast Fourier Transform
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